Development and validation of UV spectroscopic Q-absorbance ratio method for zonisamide and aripirazole in synthetic mixture

A simple, specific, accurate and precise Q-Absorbance ration spectrophotometric method was developed validated for estimation of Zonisamide Aripirazole in Synthetic Mixture. showed iso-absorptive point at 230.50nm Distilled water. The second wavelength used 240.60nm which is λmax distilled concentration the drugs determined by using ratio absorbance (λ1 =240.60 nm) (λ2 =230.50 nm). This linear both drugs; range 10-30 μg/ml λ1 R2 = 0.996 λ2 (R2 0.997) Aripirazole, 10–30 μg/mL found 0.990) 0.996). % Recovery 101.12 101.89 standard addition method. LOD to be 0.084 0.110 respectively. LOQ 0.257 0.330 as RSD less than 2.00 Repeatability, Interday Intraday precision Aripirazole. assay analyte synthetic mixture 100.48 good applicability